Research

Our research is spread across three parallels within neuromodulation

At Dr. Doshi’s Advanced Neuromodulation Research Laboratory, our current focus is to thoroughly examine connectomic DBS. In the last decade, neuroscientists have reported that the outcome of DBS is associated with stimulation of white matter tracts, and hence, tractography may have applications in prospective DBS targeting, programming, and precision DBS. However, given the current state of DWI imaging technology, we are interested in thoroughly evaluating whether connectomic targeting and programming can improve the outcome of DBS.

Ongoing Projects:

• Tractography-Based Targeting and Programming of DBS Therapies for Neurological and Psychiatric Disorders: A Randomized Double-Blind Controlled Trial

Completed Projects:

1. Directional Lead

2. Evaluation of Outcomes and Target Development in Movement Disorder Surgery (Funding: $40,000; supported by Jaslok Hospital Research Trust)

3. Autologous Mesenchymal Stem Cell Therapy in Advanced Parkinson’s Disease (Funding: $140,000; supported by Jaslok Hospital Research Trust)

4. Hardware and Surgical Complications in Deep Brain Stimulation (DBS) Surgery in India (Funding: $25,000; supported by Jaslok Hospital Research Trust)

5. Optimization of Targeting Protocols for Subthalamic Nucleus Stimulation (Funding: $35,000; supported by Jaslok Hospital Research Trust)

6. Management of Intracerebral Haematoma: Pilot study to compare Stereotactic Evacuation v/s Medical Management (2003-2005) (Funding: $30,000; supported by Jaslok Hospital Research Trust)

7. Evaluate Hardware and Surgical Complications of Deep Brain Stimulation Surgery (2006-2009) (Funding: $25,000; supported by Jaslok Hospital Research Trust)

8. Autologus Mesenchymal Stem cells implantation for Parkinson’s disease (2008-2011) (Funding: $30,000; supported by Jaslok Hospital Research Trust)

9. Evaluate the efficacy of STN lesioning in Advance Parkinson’s disease (2013) (Funding: $30,000; supported by Jaslok Hospital Research Trust)

10. Surgical

11. Motor cortex stimulation in post stroke patients (2014) (Funding: Supported by Jaslok Hospital Research Trust)

Non-Invasive Neuromodulation

Non-invasive neuromodulation refers to a group of several approaches used to modulate neurological activity transcranially, i.e., without entering the skull cavity. At Dr. Paresh Doshi's Lab, we currently work with H-coil deep Transcranial Magnetic Stimulation (dTMS) using a BrainsWay™ machine. TMS uses subtle dynamic magnetic fields to induce electrical potential in the neural networks and modulate synaptic plasticity. At JHRC’s Department of Restorative and Regenerative Medicine, we offer TMS to patients with depression, anxiety, obsessive-compulsive disorder, mild cognitive impairment, migraine, and neuropathic pain. Hence, our current research focuses on developing and validating new treatment protocols for the aforementioned conditions.

Ongoing Projects:

1. A Novel Phased Intensive Deep Transcranial Magnetic Stimulation (dTMS) to improve the stimulation-response of patients with Treatment Resistant Depression (TRD) and refractory Obsessive Compulsive Disorder (OCD)

2. Deep Transcranial Magnetic Stimulation (dTMS) for Mild Cognitive Impairment(MCI): A Proof of Concept Study

3. Deep Transcranial Magnetic Stimulation (dTMS) for Prophylaxis of Chronic Migraine: A Proof of Concept Study

Completed Research Projects:

1. Impact of Dance/Music and Meditation on Progression of Parkinson’s Disease with Mild and Moderate Severity (Supported by Jaslok Hospital & Research Centre)

Computational Neuropsychiatry and AI Integration

In today’s era of technological advancements, computational techniques such as artificial intelligence and machine learning can be extremely helpful to advance the practice of medicine. However, the scientific distance between engineers and doctors often slows the adoption of these techniques into the practice of medicine. At Dr. Paresh Doshi's Lab, we bring engineers to the patient’s bedside to bridge this distance and pursue med-tech innovation.

Our current research focuses on integrating machine learning into DBS Programming to facilitate quicker and targeted DBS Programming for STN-DBS.

Ongoing Projects:

1. Deep Brain Stimulation Programming - A Novel Approach Based on the Side Effects and Fiber Tract Imaging

Completed Research Projects:

1. Enhancing Deep Brain Stimulation Programming for Parkinson’s Disease: A Semi-Automatic Algorithm - Guided Approach using StimSearchTM- A Double Blind randomized study (Funding: $81,140; supported by Boston Scientific)